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- Title
Hematološki biljezi anemije i koncentracija C-reaktivnog proteina kod stabilne kronične opstrukcijske plućne bolesti.
- Authors
Pancirov, Dolores; Biljak, Vanja Radišić; Stjepanović, Gordana; Čepelak, Ivana
- Abstract
Background: The aim of the study was to determine the values of hematological markers of anemia and of C-reactive protein (CRP) in patients with stable chronic obstructive pulmonary disease (COPD) in order to define the presence of anemia, degree of systemic inflammation and correlations between the analytes. Material and methods: The study included 150 COPD patients (FEV1 = 48 ± 21%) and 51 control subjects (FEV1 = 106 ± 15%). Pursuant to GOLD guidelines, the patients were divided into four subgroups and according to WHO criteria for anemia into two subgroups: subjects with and those without anemia. Serum CRP concentration was determined by immunoturbidimetric method and hematological markers were determined by flow cytometry. Results: No significant differences were found in the values of erythrocytes, hemoglobin and hematocrit either between the group of all COPD patients and control subjects or between GOLD subgroups and control subjects. Anemia was present in 24% of COPD patients. CRP concentration was significantly higher in the group of all COPD patients, in all GOLD subgroups (I, lIA, IIB and Ill) and in subgroups with and without anemia as compared to control subjects (P < 0.001 all). CRP specificity and sensitivity were determined by ROC analysis and showed good diagnostic accuracy for CRP in COPD patients. Correlation coefficient between CRP and hemoglobin and hematocrit values revealed a good negative correlation (r = -0.60 and r = -0.59, respectively; P <0.001 both) only in GOLD subgroup Ill. Conclusion: CRP concentration, a marker of systemic inflammation, was significantly higher in COPD patients and in all GOLD subgroups as compared to the control group. Good negative correlation was recorded between hematocrit and hemoglobin values and advanced inflammation (CRP concentration) in GOLD subgroup Ill. The rate of anemia was in agreement with literature data.
- Subjects
ANEMIA; C-reactive protein; INFLAMMATION; HEMOGLOBINS; RESPIRATORY obstructions; OBSTRUCTIVE lung diseases patients
- Publication
Biochemia Medica, 2009, Vol 19, Issue 3, p266
- ISSN
1330-0962
- Publication type
Article