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- Title
The influence of inflammation on Polarization Colours of Collagen Fibres in focal fibrous Hyperplasia.
- Authors
Tamgadge, Sandhya; Tamgadge, Avinash; Satheesan, Evie; Shetty, Anusha
- Abstract
Brief Background Intraoral fibrous overgrowths of the soft tissues are relatively common and may be benign reactive or neoplastic and are mostly associated or occur in response to inflammation. Collagen is the principle component of such overgrowth and could be fibrous or inflammatory. There have been many studies of collagen but its correlation with inflammation has been less explored. Methodology This retrospective study composed of randomly selected samples of fibrous overgrowths from archives. Total 14 samples were selected and divided into 2 groups as such as mild to moderate (10 samples) and severe inflammation (4 samples). Sections were stained with modified picrosirius stain and observed under polarized microscope using Leica image software, to measure the thickness of collagen fibres in various grades of inflammation. Findings statistically analyzed using Unpaired t test. Observation and Results In our study, thin collagen fibres showed green to greenish yellow birefringence, whereas thick fibres showed orange to red birefringence. Thin fibres were predominant in mild inflammation and thick fibres were predominant in severe inflammation. Summary and Conclusions There is a definite correlation between inflammation and thickness of collagen fibres.
- Subjects
HYPERPLASIA; INFLAMMATION; COLLAGEN
- Publication
JIDA: Journal of Indian Dental Association, 2017, Vol 11, Issue 6, p10
- ISSN
0019-4611
- Publication type
Article