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- Title
The Effect of a Novel Viscous Polysaccharide along with Lifestyle Changes on Short-Term Weight Loss and Associated Risk Factors in Overweight and Obese Adults: An Observational Retrospective Clinical Program Analysis.
- Authors
Lyon, Michael R.; Reichert, Ronald G.
- Abstract
BACKGROUND: Viscous soluble dietary fiber has been demonstrated to reduce postprandial glycemia and may promote satiety. PolyGlycopleX® (PGX®) is a highly viscous polysaccharide manufactured by reacting glucomannan with other soluble polysaccharides using a proprietary process (EnviroSimplex®). The resulting polysaccharide (α-D-glucurono- α-D-manno-β-D-manno-β-D-glucan, α-L-gulurono-β-D-mannuronan, β-D-gluco-β-D-mannan, α-D-glucurono-α-D-manno-β-D-manno-β-D-gluco, α-L-gulurono-β-D-mannurono, β-D-gluco-β-D-mannan)is a novel entity with the highest viscosity and water-holding capacity of currently known fibers. MATERIALS & METHODS: A total of 29 sedentary overweight or obese adults (23 women; six men), ages 20-65 with a body mass index (BMI) range of25 kg/m² to 36 kg/m² participated in a clinical weight-loss program. PGX (5 g) was consumed with 500 mL water, 5-10 minutes before each meal, 2-3 times daily for 14 weeks. RESULTS: Significant reductions were observed (p<0.05) in weight (-5.79 ± 3.55 kg), waist circumference (-12.07 ± 5.56 cm), and percentage body fat (-2.43 ± 2.39%) compared to baseline values. In addition, subjects employing PGX had a significant reduction of 19.26 percent (n=17; p<0.05) and 25.51 percent (n=16; p<0.05) in total and LDL plasma cholesterol values, respectively, at the end of the study period. CONCLUSION: The consumption of PGX in concert with lifestyle modifications may be a useful strategy for weight loss in overweight and obese individuals.
- Subjects
DIETARY fiber; POLYSACCHARIDES; CHOLESTEROL; OVERWEIGHT persons; OBESITY
- Publication
Alternative Medicine Review, 2010, Vol 15, Issue 1, p68
- ISSN
1089-5159
- Publication type
Article