We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Immunomodulating Hydrogels as Stealth Platform for Drug Delivery Applications.
- Authors
Rezaei, Zahra; Yilmaz-Aykut, Dilara; Tourk, Fatima Mumtaza; Bassous, Nicole; Barroso-Zuppa, Margot; Shawl, Asif Iqbal; Ashraf, Syed Salman; Avci, Huseyin; Hassan, Shabir
- Abstract
Non-targeted persistent immune activation or suppression by different drug delivery platforms can cause adverse and chronic physiological effects including cancer and arthritis. Therefore, non-toxic materials that do not trigger an immunogenic response during delivery are crucial for safe and effective in vivo treatment. Hydrogels are excellent candidates that can be engineered to control immune responses by modulating biomolecule release/adsorption, improving regeneration of lymphoid tissues, and enhancing function during antigen presentation. This review discusses the aspects of hydrogel-based systems used as drug delivery platforms for various diseases. A detailed investigation on different immunomodulation strategies for various delivery options and deliberate upon the outlook of such drug delivery platforms are conducted.
- Subjects
DRUG delivery systems; HYDROGELS; AUTOMATIC control systems; LYMPHOID tissue; ANTIGEN presentation; IMMUNOSUPPRESSION
- Publication
Pharmaceutics, 2022, Vol 14, Issue 10, pN.PAG
- ISSN
1999-4923
- Publication type
Article
- DOI
10.3390/pharmaceutics14102244