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- Title
Molecular distribution of preformed thyroglobulin immune complexes.
- Authors
Husby, S.; Steensgaard, J.; U. Feldt-Rasmussen; Date, J.
- Abstract
Thyroglobulin anti-thyroglobulin immune complexes with human antibodies from four patient sera were preformed in a wide range of antigen:antibody ratios and run in 5%–40% sucrose gradients. The fractionation showed simple distributions of thyroglobulin molecules in immune complexes, especially in far antigen and far antibody excess. A computer simulation analysis which utilized the experimental presumptions and assumed an association constant in the order of 109, showed a large degree of similarity to the experimental results. Thus, a thermodynamically simple explanation of immune complex formation did not contradict the experimental thyroglobulin anti-thyroglobulin complex formation.
- Subjects
THYROGLOBULIN; GLYCOPROTEINS; IMMUNOGLOBULINS; IMMUNE complexes; ANTIGENS; IMMUNOLOGY
- Publication
Immunology, 1983, Vol 48, Issue 2, p401
- ISSN
0019-2805
- Publication type
Article