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- Title
Reply: Letter to the editor.
- Abstract
We also consider that fibroblasts residing in OA-IFP (some of them might be OA-IFP stem cells) play important roles during disease progression, since these cells have central roles in tissue fibrosis. Based on these observations, we consider that fibrosis may induce both neovascularization and invasion of nerve fiber endings into IFP, which may decrease the pain threshold in the knee joint. On behalf of all authors, I really thank Dr. Stocco, Dr. Porzionato, Dr. De Caro, and Dr. Macchi for sharing their important observations with us.1 I agree that characterization of osteoarthritis-infrapatellar fat pad (OA-IFP) stem cells and analyses of physiological functions of those cells are quite important subjects to understand OA pathogenesis.
- Subjects
MYELOID cells; NATRIURETIC peptides; NEURONS; SENSORY receptors; VASCULAR endothelial cells; JOINT pain; EXPERIMENTAL arthritis
- Publication
Journal of Orthopaedic Research, 2021, Vol 39, Issue 12, p2535
- ISSN
0736-0266
- Publication type
Article
- DOI
10.1002/jor.25028