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- Title
The impact of retinoids on the thyroid axis.
- Authors
Graeppi-Dulac, Julia; Vlaeminck-Guillem, Virginie; Perier-Muzet, Marie; Dalle, Stéphane; Orgiazzi, Jacques
- Abstract
Bexarotene (Targretin), approved since 1999 as a second-line treatment for late stage cutaneous T-cell lymphomas, has been shown to induce significant hypothyroidism through TSH suppression. This review revisits, through a case report, mechanisms by which rexinoids repress the expression of TSHB gene as well as αTSH and TRH genes. It appears that rexinoids suppress TSH independently from tri-iodothyronine. Bexarotene also differently affects the gene expression of deiodinases 1 and 2 as well as the peripheral clearance of thyroxine. These data might open new ways of research on the potential interaction between thyroid axis and endogenous rexinoids.
- Subjects
HYPOTHALAMIC-pituitary-thyroid axis; RETINOIDS; INTERPHOTORECEPTOR retinoid-binding protein; LYMPHOPROLIFERATIVE disorders; THYROID hormones; THYROGLOBULIN; RETICULOENDOTHELIAL granulomas
- Publication
European Journal of Endocrinology, 2014, Vol 170, Issue 6, pR253
- ISSN
0804-4643
- Publication type
Article
- DOI
10.1530/EJE-13-0920