We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Peroxisome Proliferator-Activated Receptors as Mediators of Phthalate-Induced Effects in the Male and Female Reproductive Tract: Epidemiological and Experimental Evidence.
- Authors
Latini, Giuseppe; Scoditti, Egeria; Verrotti, Alberto; De Felice, Claudio; Massaro, Marika
- Abstract
There is growing evidence that male as well as female reproductive function has been declining in human and wildlife populations over the last 40 years. Several factors such as lifestyle or environmental xenobiotics other than genetic factors may play a role in determining adverse effects on reproductive health. Among the environmental xenobiotics phthalates, a family of man-made pollutants are suspected to interfere with the function of the endocrine system and therefore to be endocrine disruptors. The definition of endocrine disruption is today extended to broader endocrine regulations, and includes activation of metabolic sensors, such as the peroxisome proliferator-activated receptors (PPARs). Toxicological studies have shown that phthalates can activate a subset of PPARs. Here, we analyze the epidemiological and experimental evidence linking phthalate exposure to both PPAR activation and adverse effects on male and female reproductive health.
- Subjects
PEROXISOMES; NUCLEAR receptors (Biochemistry); XENOBIOTICS; PHTHALATE esters; GENITALIA; REPRODUCTIVE health; ENDOCRINE disruptors
- Publication
PPAR Research, 2008, p1
- ISSN
1687-4757
- Publication type
Article
- DOI
10.1155/2008/359267