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- Title
Epidemiological characterization of viral etiological agents of the central nervous system infections among hospitalized patients in Egypt between 2016 and 2019.
- Authors
Roshdy, Wael H.; Kandeil, Ahmed; Fahim, Manal; Naguib, Nourhan Y.; Mohsen, Gehad; Shawky, Shaymaa; Abd El-Fattah, Marwa M.; Naguib, Amel; Salamony, Azza; Shamikh, Yara I.; Moawad, Mahmoud; Guindy, Nancy El; Khalifa, Mohamed K.; Abbas, Eman; Galal, Ramy; Hassany, Mohamed; Ibrahem, Mohamed; El-Shesheny, Rabeh; Asem, Noha; Kandeel, Amr
- Abstract
Viral infections of the central nervous system (CNS) are common worldwide and result in considerable morbidity and mortality associated with neurologic illness. Until now, there have been no epidemiologic data regarding viruses causing aseptic meningitis, encephalitis, and CNS infections in Egypt. We investigated 1735 archived cerebrospinal fluid samples collected from Egyptian patients between 2016 and 2019 and performed molecular characterization for infection for12 different viruses: herpes simplex viruses 1 and 2 (HSV-1 and HSV-2), varicella-zoster virus (VZV), Epstein–Barr virus (EBV), cytomegalovirus (CMV), human herpesviruses 6 and 7 (HHV-6 and HHV-7), human enteroviruses (HEVs), human parechovirus (HPeV), parvovirus B19 (B19V), adenovirus (AdV), and mumps virus (MuV). All included samples were negative for bacterial infection. Our results indicated a relatively high prevalence of viral infection, with HEVs being the most prevalent viruses, followed by HSV-1, EBV, and then HSV-2. The highest prevalence was among male patients, peaking during the summer. Data obtained from this study will contribute to improving the clinical management of viral infections of the CNS in Egypt.
- Subjects
EGYPT; CENTRAL nervous system infections; CENTRAL nervous system viral diseases; VIRUS diseases; HOSPITAL patients; VARICELLA-zoster virus; PLANT viruses
- Publication
Virology Journal, 2023, Vol 20, Issue 1, p1
- ISSN
1743-422X
- Publication type
Article
- DOI
10.1186/s12985-023-02079-y