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- Title
Multiple intracellular pathogen infections with ocular pathologies associated with adult-onset immunodeficiency due to anti-interferon-γ autoantibodies: a case report.
- Authors
Ning, Yan; Yu, Qingliang; Liang, Hanlin; Wu, Siyao; Liang, Siqiao; Liang, Xiaona; He, Zhiyi
- Abstract
Background: Autoantibodies against interferon-γ (IFN-γ) can inhibit IFN-γ-dependent signal transducer and activator of transcription 1 phosphorylation and thus increase the risk of infection with intracellular pathogens, such as Talaromyces marneffei (TM), nontuberculous mycobacteria (NTMs), and Mycobacterium tuberculosis (TB). Here, we report a rare case of triple infection caused by TM, NTM, and TB in a human immunodeficiency virus–negative patient. Case presentation: A middle-aged female was admitted to our hospital after experiencing recurrent rash, cough, and expectoration for 4 months. She was successively diagnosed with NTM, TM, and TB infections without conventional immunosuppression-associated factors. However, after effective anti-infective treatment, the patient was confirmed to have allergic conjunctivitis and was successfully treated with corticosteroids and immunosuppressants. The most conspicuous characteristics were recurrent infection and immune disorders. Conclusions: High-titer anti-IFN-γ autoantibodies are strongly associated with severe and disseminated infections, such as NTM, TM, and TB. It is characterized by persistently high degree of inflammation and high immunoglobin levels.
- Subjects
INTRACELLULAR pathogens; ALLERGIC conjunctivitis; AUTOANTIBODIES; IMMUNOLOGIC diseases; MYCOBACTERIUM tuberculosis; PATHOLOGY
- Publication
BMC Infectious Diseases, 2024, Vol 24, p1
- ISSN
1471-2334
- Publication type
Case Study
- DOI
10.1186/s12879-024-09003-x