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- Title
Extracellular vesicles released from irradiated neonatal mouse cheek tissue increased cell survival after radiation.
- Authors
Ariyoshi, Kentaro; Hiroyama, Yota; Fujiwara, Naoya; Miura, Tomisato; Kasai, Kosuke; Nakata, Akifumi; Fujishima, Yohei; Goh, Valerie Swee Ting; Yoshida, Mitsuaki A
- Abstract
Alopecia is one of the common symptoms after high-dose radiation exposure. In our experiments, neonatal mice that received 7 Gy X-ray exhibited defects in overall hair growth, except for their cheeks. This phenomenon might suggest that some substances were secreted and prevented hair follicle loss in the infant tissues around their cheeks after radiation damage. In this study, we focused on exosome-like vesicles (ELV) secreted from cheek skin tissues and back skin tissues, as control, and examined their radiation protective effects on mouse fibroblast cell lines. We observed that ELV from irradiated cheek skin showed protective effects from radiation. Our results suggest that ELV from radiation-exposed cheek skin tissue is one of the secreted factors that prevent hair follicle loss after high-dose radiation.
- Subjects
FIBROBLASTS; CELL lines
- Publication
Journal of Radiation Research, 2021, Vol 62, Issue 1, p73
- ISSN
0449-3060
- Publication type
Article
- DOI
10.1093/jrr/rraa106