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- Title
Efficacy of Clostridium butyricum preparation concomitantly with Helicobacter pylori eradication therapy in relation to changes in the intestinal microbiota.
- Authors
Imase, Kyoto; Takahashi, Motomichi; Tanaka, Akifumi; Tokunaga, Kengo; Sugano, Hajime; Tanaka, Mamoru; Ishida, Hitoshi; Kamiya, Shigeru; Takahashi, Shin'ichi
- Abstract
Antibiotic associated diarrhea due to human intestinal microbiota abnormalities is a side effect of H. pylori eradication therapy. We examined intestinal microbiota changes during H. pylori eradication therapy and the preventive effect of CBM588 as a probiotic agent. Nineteen patients with gastro-duodenal ulcer were randomly divided into three groups: group A (without probiotics), group B (with regular doses of CBM588) and group C (with double doses of CBM588). The incidence of diarrhea and soft stools during H. pylori eradication therapy was 43% in group A and 14% in group B, while none of the patients in group C reported diarrhea or soft stools. Both bacterial counts and detection rates of bifidobacteria and/or obligate anaerobe were decreased by eradication therapy. However, bacterial counts of obligate anaerobes in group C were significantly higher than in group A ( P < 0.05). Additionally, during eradication therapy C. difficile toxin A was detected in both group A and group B but not in group C. In conclusion, these results indicate that H. pylori eradication therapy induces antibiotic associated diarrhea due to abnormalities in intestinal microbiota and/or C. difficile. However, these side effects might be prevented by probiotics.
- Subjects
CLOSTRIDIUM butyricum; HELICOBACTER pylori infections; INTESTINAL infections; ANTIBIOTICS; ULCER treatment; BIFIDOBACTERIUM
- Publication
Microbiology & Immunology, 2008, Vol 52, Issue 3, p156
- ISSN
0385-5600
- Publication type
Article
- DOI
10.1111/j.1348-0421.2008.00026.x