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Adaptive Evolution of Scorpion Sodium Channel Toxins.
Published in:
Journal of Molecular Evolution, 2004, v. 58, n. 2, p. 145, doi. 10.1007/s00239-003-2534-2
By:
- Zhu, Shunyi;
- Bosmans, Frank;
- Tytgat, Jan
Publication type:
Article
Efficient enzymatic cyclization of an inhibitory cystine knot-containing peptide.
Published in:
Biotechnology & Bioengineering, 2016, v. 113, n. 10, p. 2202, doi. 10.1002/bit.25993
By:
- Kwon, Soohyun;
- Bosmans, Frank;
- Kaas, Quentin;
- Cheneval, Olivier;
- Conibear, Anne C.;
- Rosengren, K. Johan;
- Wang, Conan K.;
- Schroeder, Christina I.;
- Craik, David J.
Publication type:
Article
Binary architecture of the Nav1.2-β2 signaling complex.
Published in:
eLife, 2016, p. 1, doi. 10.7554/eLife.10960
By:
- Das, Samir;
- Gilchrist, John;
- Bosmans, Frank;
- Van Petegem, Filip
Publication type:
Article
Molecular basis of the mammalian potency of the scorpion α-like toxin, BmK M1.
Published in:
FASEB Journal, 2005, v. 19, n. 6, p. 594, doi. 10.1096/fj.04-2485fje
By:
- Li-Hui Liu;
- Bosmans, Frank;
- Maertens, Chantal;
- Zhu, Ron-Han;
- Da-Cheng Wang;
- Tytgat, Jan
Publication type:
Article
A MULTI-HIT MODEL OF LONG COVID PATHOPHYSIOLOGY: THE INTERACTION BETWEEN IMMUNE TRIGGERS AND NERVOUS SYSTEM SIGNALING.
Published in:
Transactions of the American Clinical & Climatological Association, 2024, v. 134, p. 149
By:
- BROCK, MALCOLM V.;
- BOSMANS, FRANK
Publication type:
Article
In vivo spatiotemporal control of voltage-gated ion channels by using photoactivatable peptidic toxins.
Published in:
Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-27974-w
By:
- Montnach, Jérôme;
- Blömer, Laila Ananda;
- Lopez, Ludivine;
- Filipis, Luiza;
- Meudal, Hervé;
- Lafoux, Aude;
- Nicolas, Sébastien;
- Chu, Duong;
- Caumes, Cécile;
- Béroud, Rémy;
- Jopling, Chris;
- Bosmans, Frank;
- Huchet, Corinne;
- Landon, Céline;
- Canepari, Marco;
- De Waard, Michel
Publication type:
Article
The scorpion toxin Bot IX is a potent member of the α‐like family and has a unique N‐terminal sequence extension.
Published in:
2018
By:
- Martin‐Eauclaire, Marie‐France;
- Salvatierra, Juan;
- Mansuelle, Pascal;
- Bosmans, Frank;
- Bougis, Pierre E.
Publication type:
Correction Notice
The scorpion toxin Bot IX is a potent member of the α-like family and has a unique N-terminal sequence extension.
Published in:
FEBS Letters, 2016, v. 590, n. 18, p. 3221, doi. 10.1002/1873-3468.12357
By:
- Martin-Eauclaire, Marie-France;
- Salvatierra, Juan;
- Bosmans, Frank;
- Bougis, Pierre E.
Publication type:
Article
Using voltage-sensor toxins and their molecular targets to investigate NaV1.8 gating.
Published in:
Journal of Physiology, 2018, v. 596, n. 10, p. 1863, doi. 10.1113/JP275102
By:
- Gilchrist, John;
- Bosmans, Frank
Publication type:
Article
Neonatal NaV 1.5 channels: pharmacological distinctiveness of a cancer-related voltage-gated sodium channel splice variant.
Published in:
2022
By:
- Fraser, Scott P.;
- Onkal, Rustem;
- Theys, Margaux;
- Bosmans, Frank;
- Djamgoz, Mustafa B. A.
Publication type:
journal article
A distinct sodium channel voltage-sensor locus determines insect selectivity of the spider toxin Dc1a.
Published in:
Nature Communications, 2014, v. 5, n. 7, p. 4350, doi. 10.1038/ncomms5350
By:
- Bende, Niraj S.;
- Dziemborowicz, Sławomir;
- Mobli, Mehdi;
- Herzig, Volker;
- Gilchrist, John;
- Wagner, Jordan;
- Nicholson, Graham M.;
- King, Glenn F.;
- Bosmans, Frank
Publication type:
Article
The Scorpion Toxin Tf2 from Tityus fasciolatus Promotes Nav1.3 Opening.
Published in:
PLoS ONE, 2015, v. 10, n. 6, p. 1, doi. 10.1371/journal.pone.0128578
By:
- Camargos, Thalita S.;
- Bosmans, Frank;
- Rego, Solange C.;
- Mourão, Caroline B. F.;
- Schwartz, Elisabeth F.
Publication type:
Article
The insecticidal spider toxin SFI1 is a knottin peptide that blocks the pore of insect voltage-gated sodium channels via a large β-hairpin loop.
Published in:
FEBS Journal, 2015, v. 282, n. 5, p. 904, doi. 10.1111/febs.13189
By:
- Bende, Niraj S.;
- Dziemborowicz, Sławomir;
- Herzig, Volker;
- Ramanujam, Venkatraman;
- Brown, Geoffrey W.;
- Bosmans, Frank;
- Nicholson, Graham M.;
- King, Glenn F.;
- Mobli, Mehdi
Publication type:
Article
The Dragon's Paralysing Spell: Evidence of Sodium and Calcium Ion Channel Binding Neurotoxins in Helodermatid and Varanid Lizard Venoms.
Published in:
Toxins, 2021, v. 13, n. 8, p. 549, doi. 10.3390/toxins13080549
By:
- Dobson, James S.;
- Harris, Richard J.;
- Zdenek, Christina N.;
- Huynh, Tam;
- Hodgson, Wayne C.;
- Bosmans, Frank;
- Fourmy, Rudy;
- Violette, Aude;
- Fry, Bryan G.
Publication type:
Article
Chemical Synthesis, Proper Folding, Nav Channel Selectivity Profile and Analgesic Properties of the Spider Peptide Phlotoxin 1.
Published in:
Toxins, 2019, v. 11, n. 6, p. 367, doi. 10.3390/toxins11060367
By:
- Nicolas, Sébastien;
- Zoukimian, Claude;
- Bosmans, Frank;
- Montnach, Jérôme;
- Diochot, Sylvie;
- Cuypers, Eva;
- De Waard, Stephan;
- Béroud, Rémy;
- Mebs, Dietrich;
- Craik, David;
- Boturyn, Didier;
- Lazdunski, Michel;
- Tytgat, Jan;
- De Waard, Michel
Publication type:
Article
Insect-Active Toxins with Promiscuous Pharmacology from the African Theraphosid Spider Monocentropus balfouri.
Published in:
Toxins, 2017, v. 9, n. 5, p. 155, doi. 10.3390/toxins9050155
By:
- Smith, Jennifer J.;
- Herzig, Volker;
- Ikonomopoulou, Maria P.;
- Dziemborowicz, Sławomir;
- Bosmans, Frank;
- Nicholson, Graham M.;
- King, Glenn F.
Publication type:
Article
Animal Toxins Can Alter the Function of Nav1.8 and Nav1.9.
Published in:
Toxins, 2012, v. 4, n. 8, p. 620, doi. 10.3390/toxins4080620
By:
- Gilchrist, John;
- Bosmans, Frank
Publication type:
Article
Homozygous SCN1B variants causing early infantile epileptic encephalopathy 52 affect voltage‐gated sodium channel function.
Published in:
Epilepsia (Series 4), 2021, v. 62, n. 6, p. e82, doi. 10.1111/epi.16913
By:
- Scala, Marcello;
- Efthymiou, Stephanie;
- Sultan, Tipu;
- De Waele, Jolien;
- Panciroli, Marta;
- Salpietro, Vincenzo;
- Maroofian, Reza;
- Striano, Pasquale;
- Van Petegem, Filip;
- Houlden, Henry;
- Bosmans, Frank
Publication type:
Article
Anxiety and dysautonomia symptoms in patients with a NaV1.7 mutation and the potential benefits of low-dose short-acting guanfacine.
Published in:
Clinical Autonomic Research, 2024, v. 34, n. 1, p. 191, doi. 10.1007/s10286-023-01004-1
By:
- de Cássia Collaço, Rita;
- Lammens, Maxime;
- Blevins, Carley;
- Rodgers, Kristen;
- Gurau, Andrei;
- Yamauchi, Suguru;
- Kim, Christine;
- Forrester, Jeannine;
- Liu, Edward;
- Ha, Jinny;
- Mei, Yuping;
- Boehm, Corrine;
- Wohler, Elizabeth;
- Sobreira, Nara;
- Rowe, Peter C.;
- Valle, David;
- Brock, Malcolm V.;
- Bosmans, Frank
Publication type:
Article
Deconstructing voltage sensor function and pharmacology in sodium channels.
Published in:
Nature, 2008, v. 456, n. 7219, p. 202, doi. 10.1038/nature07473
By:
- Bosmans, Frank;
- Martin-Eauclaire, Marie-France;
- Swartz, Kenton J.
Publication type:
Article
The first potassium channel toxin from the venom of the Iranian scorpion Odonthobuthus doriae
Published in:
FEBS Letters, 2006, v. 580, n. 26, p. 6254, doi. 10.1016/j.febslet.2006.10.029
By:
- Abdel-Mottaleb, Yousra;
- Clynen, Elke;
- Jalali, Amir;
- Bosmans, Frank;
- Vatanpour, Hossein;
- Schoofs, Liliane;
- Tytgat, Jan
Publication type:
Article
OD1, the first toxin isolated from the venom of the scorpion Odonthobuthus doriae active on voltage-gated Na+ channels
Published in:
FEBS Letters, 2005, v. 579, n. 19, p. 4181, doi. 10.1016/j.febslet.2005.06.052
By:
- Jalali, Amir;
- Bosmans, Frank;
- Amininasab, Mehriar;
- Clynen, Elke;
- Cuypers, Eva;
- Zaremirakabadi, Abbas;
- Sarbolouki, Mohammad-Nabi;
- Schoofs, Liliane;
- Vatanpour, Hossein;
- Tytgat, Jan
Publication type:
Article
The poison Dart frog's batrachotoxin modulates Nav1.8
Published in:
FEBS Letters, 2004, v. 577, n. 1/2, p. 245, doi. 10.1016/j.febslet.2004.10.017
By:
- Bosmans, Frank;
- Maertens, Chantal;
- Verdonck, Fons;
- Tytgat, Jan
Publication type:
Article
Function and solution structure of hainantoxin-I, a novel insect sodium channel inhibitor from the Chinese bird spider Selenocosmia hainana
Published in:
FEBS Letters, 2003, v. 555, n. 3, p. 616, doi. 10.1016/S0014-5793(03)01303-6
By:
- Li, Dongling;
- Xiao, Yucheng;
- Hu, Weijun;
- Xie, Jinyun;
- Bosmans, Frank;
- Tytgat, Jan;
- Liang, Songping
Publication type:
Article
The sea anemone Bunodosoma granulifera contains surprisingly efficacious and potent insect-selective toxins
Published in:
FEBS Letters, 2002, v. 532, n. 1/2, p. 131, doi. 10.1016/S0014-5793(02)03653-0
By:
- Bosmans, Frank;
- Aneiros, Abel;
- Tytgat, Jan
Publication type:
Article
A disease mutation reveals a role for NaV1.9 in acute itch.
Published in:
2018
By:
- Salvatierra, Juan;
- Diaz-Bustamante, Marcelo;
- Meixiong, James;
- Tierney, Elaine;
- Xinzhong Dong;
- Bosmans, Frank;
- Dong, Xinzhong
Publication type:
journal article
Interactions between lipids and voltage sensor paddles detected with tarantula toxins.
Published in:
Nature Structural & Molecular Biology, 2009, v. 16, n. 10, p. 1080, doi. 10.1038/nsmb.1679
By:
- Milescu, Mirela;
- Bosmans, Frank;
- Seungkyu Lee;
- Alabi, AbdulRasheed A.;
- Jae Il Kim;
- Swartz, Kenton J.
Publication type:
Article
Corrigendum: Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a.
Published in:
Scientific Reports, 2017, p. 46816, doi. 10.1038/srep46816
By:
- Deuis, Jennifer R.;
- Dekan, Zoltan;
- Wingerd, Joshua S.;
- Smith, Jennifer J.;
- Munasinghe, Nehan R.;
- Bhola, Rebecca F.;
- Imlach, Wendy L.;
- Herzig, Volker;
- Armstrong, David A.;
- Rosengren, K. Johan;
- Bosmans, Frank;
- Waxman, Stephen G.;
- Dib-Hajj, Sulayman D.;
- Escoubas, Pierre;
- Minett, Michael S.;
- Christie, Macdonald J.;
- King, Glenn F.;
- Alewood, Paul F.;
- Lewis, Richard J.;
- Wood, John N.
Publication type:
Article
Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a.
Published in:
Scientific Reports, 2017, p. 40883, doi. 10.1038/srep40883
By:
- Deuis, Jennifer R.;
- Dekan, Zoltan;
- Wingerd, Joshua S.;
- Smith, Jennifer J.;
- Munasinghe, Nehan R.;
- Bhola, Rebecca F.;
- Imlach, Wendy L.;
- Herzig, Volker;
- Armstrong, David A.;
- Rosengren, K. Johan;
- Bosmans, Frank;
- Waxman, Stephen G.;
- Dib-Hajj, Sulayman D.;
- Escoubas, Pierre;
- Minett, Michael S.;
- Christie, Macdonald J.;
- King, Glenn F.;
- Alewood, Paul F.;
- Lewis, Richard J.;
- Wood, John N.
Publication type:
Article
Molecular basis of the remarkable species selectivity of an insecticidal sodium channel toxin from the African spider Augacephalus ezendami.
Published in:
Scientific Reports, 2016, p. 29538, doi. 10.1038/srep29538
By:
- Herzig, Volker;
- Ikonomopoulou, Maria;
- Smith, Jennifer J.;
- Dziemborowicz, Sławomir;
- Gilchrist, John;
- Kuhn-Nentwig, Lucia;
- Rezende, Fernanda Oliveira;
- Moreira, Luciano Andrade;
- Nicholson, Graham M.;
- Bosmans, Frank;
- King, Glenn F.
Publication type:
Article
Seven novel modulators of the analgesic target NaV 1.7 uncovered using a high-throughput venom-based discovery approach.
Published in:
2015
By:
- Klint, Julie K;
- Smith, Jennifer J;
- Vetter, Irina;
- Rupasinghe, Darshani B;
- Er, Sing Yan;
- Senff, Sebastian;
- Herzig, Volker;
- Mobli, Mehdi;
- Lewis, Richard J;
- Bosmans, Frank;
- King, Glenn F
Publication type:
journal article
Seven novel modulators of the analgesic target NaV1.7 uncovered using a high-throughput venom-based discovery approach.
Published in:
British Journal of Pharmacology, 2015, v. 172, n. 10, p. 2445, doi. 10.1111/bph.13081
By:
- Klint, Julie K;
- Smith, Jennifer J;
- Vetter, Irina;
- Rupasinghe, Darshani B;
- Er, Sing Yan;
- Senff, Sebastian;
- Herzig, Volker;
- Mobli, Mehdi;
- Lewis, Richard J;
- Bosmans, Frank;
- King, Glenn F
Publication type:
Article

Found: 32

Adaptive Evolution of Scorpion Sodium Channel Toxins.

Efficient enzymatic cyclization of an inhibitory cystine knot-containing peptide.

Binary architecture of the Na<sub>v</sub>1.2-β2 signaling complex.

Molecular basis of the mammalian potency of the scorpion α-like toxin, BmK M1.

A MULTI-HIT MODEL OF LONG COVID PATHOPHYSIOLOGY: THE INTERACTION BETWEEN IMMUNE TRIGGERS AND NERVOUS SYSTEM SIGNALING.

In vivo spatiotemporal control of voltage-gated ion channels by using photoactivatable peptidic toxins.

The scorpion toxin Bot IX is a potent member of the α‐like family and has a unique N‐terminal sequence extension.

The scorpion toxin Bot IX is a potent member of the α-like family and has a unique N-terminal sequence extension.

Using voltage-sensor toxins and their molecular targets to investigate Na<sub>V</sub>1.8 gating.

Neonatal Na<sub>V</sub> 1.5 channels: pharmacological distinctiveness of a cancer-related voltage-gated sodium channel splice variant.

A distinct sodium channel voltage-sensor locus determines insect selectivity of the spider toxin Dc1a.

The Scorpion Toxin Tf2 from Tityus fasciolatus Promotes Na<sub>v</sub>1.3 Opening.

The insecticidal spider toxin SFI1 is a knottin peptide that blocks the pore of insect voltage-gated sodium channels via a large β-hairpin loop.

The Dragon's Paralysing Spell: Evidence of Sodium and Calcium Ion Channel Binding Neurotoxins in Helodermatid and Varanid Lizard Venoms.

Chemical Synthesis, Proper Folding, Nav Channel Selectivity Profile and Analgesic Properties of the Spider Peptide Phlotoxin 1.

Insect-Active Toxins with Promiscuous Pharmacology from the African Theraphosid Spider Monocentropus balfouri.

Animal Toxins Can Alter the Function of Nav1.8 and Nav1.9.

Homozygous SCN1B variants causing early infantile epileptic encephalopathy 52 affect voltage‐gated sodium channel function.

Anxiety and dysautonomia symptoms in patients with a Na<sub>V</sub>1.7 mutation and the potential benefits of low-dose short-acting guanfacine.

Deconstructing voltage sensor function and pharmacology in sodium channels.

The first potassium channel toxin from the venom of the Iranian scorpion Odonthobuthus doriae

OD1, the first toxin isolated from the venom of the scorpion Odonthobuthus doriae active on voltage-gated Na<sup>+</sup> channels

The poison Dart frog's batrachotoxin modulates Na<sub>v</sub>1.8

Function and solution structure of hainantoxin-I, a novel insect sodium channel inhibitor from the Chinese bird spider Selenocosmia hainana

The sea anemone Bunodosoma granulifera contains surprisingly efficacious and potent insect-selective toxins

A disease mutation reveals a role for NaV1.9 in acute itch.

Interactions between lipids and voltage sensor paddles detected with tarantula toxins.

Corrigendum: Pharmacological characterisation of the highly Na<sub>V</sub>1.7 selective spider venom peptide Pn3a.

Pharmacological characterisation of the highly Na<sub>V</sub>1.7 selective spider venom peptide Pn3a.

Molecular basis of the remarkable species selectivity of an insecticidal sodium channel toxin from the African spider Augacephalus ezendami.

Seven novel modulators of the analgesic target NaV 1.7 uncovered using a high-throughput venom-based discovery approach.

Seven novel modulators of the analgesic target Na<sub>V</sub>1.7 uncovered using a high-throughput venom-based discovery approach.