We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Hypothalamic inflammation in obesity and metabolic disease.
- Authors
Jais, Alexander; Brüning, Jens C.
- Abstract
Over the last years, hypothalamic inflammation has been linked to the development and progression of obesity and its sequelae. There is accumulating evidence that this inflammation not only impairs energy balance but also contributes to obesity-associated insulin resistance. Elevated activation of key inflammatory mediators such as JNK and IκB kinase (IKK) occurs rapidly upon consumption of a high-fat diet, even prior to significant weight gain. This activation of hypothalamic inflammatory pathways results in the uncoupling of caloric intake and energy expenditure, fostering overeating and further weight gain. In addition, these inflammatory processes contribute to obesity-associated insulin resistance and deterioration of glucose metabolism via altered neurocircuit functions. An understanding of the contributions of different neuronal and non-neuronal cell types to hypothalamic inflammatory processes, and delineation of the differences and similarities between acute and chronic activation of these inflammatory pathways, will be critical for the development of novel therapeutic strategies for the treatment of obesity and metabolic syndrome.
- Subjects
HYPOTHALAMUS diseases; OBESITY treatment; METABOLIC disorder treatment; INFLAMMATION; JANUS kinases
- Publication
Journal of Clinical Investigation, 2017, Vol 127, Issue 1, p24
- ISSN
0021-9738
- Publication type
journal article
- DOI
10.1172/JCI88878