We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Repurposing staples for viruses: applying peptide design to RSV prophylaxis.
- Authors
Katen, Sarah P.; Dermody, Terence S.
- Abstract
Respiratory syncytial virus (RSV) is responsible for lower respiratory tract infections and annually results in 200,000 deaths worldwide. Despite the burden of RSV-associated disease, treatments and preventative measures are limited. In this issue of JCI, Bird and colleagues describe their work using a peptide stapling technique that allowed synthesis of a stable peptide mimic of a portion of the RSV fusion protein. Pretreatment of cells with the stable peptide effectively blocked virus entry. When introduced into mice prior to RSV exposure, the peptide produced a substantial prophylactic effect. This work provides a new way forward in RSV prevention.
- Publication
Journal of Clinical Investigation, 2014, Vol 124, Issue 5, p1889
- ISSN
0021-9738
- Publication type
Article
- DOI
10.1172/JCI75797