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- Title
A comprehensive molecular interaction map of the budding yeast cell cycle.
- Authors
Kaizu, Kazunari; Ghosh, Samik; Matsuoka, Yukiko; Moriya, Hisao; Shimizu‐Yoshida, Yuki; Kitano, Hiroaki
- Abstract
With the accumulation of data on complex molecular machineries coordinating cell-cycle dynamics, coupled with its central function in disease patho-physiologies, it is becoming increasingly important to collate the disparate knowledge sources into a comprehensive molecular network amenable to systems-level analyses. In this work, we present a comprehensive map of the budding yeast cell-cycle, curating reactions from ~600 original papers. Toward leveraging the map as a framework to explore the underlying network architecture, we abstract the molecular components into three planes—signaling, cell-cycle core and structural planes. The planar view together with topological analyses facilitates network-centric identification of functions and control mechanisms. Further, we perform a comparative motif analysis to identify around 194 motifs including feed-forward, mutual inhibitory and feedback mechanisms contributing to cell-cycle robustness. We envisage the open access, comprehensive cell-cycle map to open roads toward community-based deeper understanding of cell-cycle dynamics.
- Publication
Molecular Systems Biology, 2010, Vol 6, Issue 1, p1
- ISSN
1744-4292
- Publication type
Article
- DOI
10.1038/msb.2010.73