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- Title
Effects of 660 nm low-level laser therapy on muscle healing process after cryolesion.
- Authors
Rodrigues, Natalia C.; Assis, Lívia; Fernandes, Kelly R.; Magri, Angela; Ribeiro, Daniel A.; Brunelli, Roberta; Abreu, Daniela C. C.; Renno, Ana Claudia M.
- Abstract
The aim of this study was to evaluate the effects of 660 nm low-level laser therapy (LLLT) on muscle regeneration after cryolesion in rat tibialis anterior muscle. Sixty-three Wistar rats were divided into a control group, 10 J/cm2 laser-treated group, and 50 J/cm2 laser-treated group. Each group formed three subgroups (n = 7 per group), and the animals were sacrificed 7, 14, or 21 d after lesion. Histopathological findings revealed a lower inflammatory process in the laser-treated groups after 7 d. After 14 d, irradiated animals at both fluences showed higher granulation tissue, new muscle fibers, and organized muscle structure. After 21 d, full tissue repair was observed in all groups. Moreover, irradiated animals at both fluences showed smaller necrosis area in the first experimental period evaluated. MyoD immunoexpression was observed in both treated groups 7 d postinjury. Myogenin immunoexpression was detected after 7 and 14 d. The higher fluence increased the number of blood vessels after 14 and 21 d. These results suggest that LLLT, at both fluences, positively affects injured skeletal muscle in rats, accelerating the muscle-regeneration process.
- Subjects
MUSCLE physiology; WOUND care; SKELETAL muscle injuries; MUSCLE protein metabolism; ANALYSIS of variance; ANIMAL experimentation; BIOLOGICAL models; BIOPHYSICS; CELL differentiation; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MEDICAL lasers; RESEARCH methodology; NEOVASCULARIZATION; HEALTH outcome assessment; PROBABILITY theory; RATS; RESEARCH funding; STATISTICS; WOUND healing; DATA analysis; TREATMENT effectiveness; DATA analysis software; SKELETAL muscle; ANATOMY
- Publication
Journal of Rehabilitation Research & Development, 2013, Vol 50, Issue 7, p985
- ISSN
0748-7711
- Publication type
Article
- DOI
10.1682/JRRD.2012.08.0147