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- Title
Dose-excretion relationship in tetrachloroethylene-exposed workers and the effect of tetrachloroethylene co-exposure on trichloroethylene metabolism.
- Authors
Seiji, Kazunori; Inoue, Osamu; Jin, Chui; Liu, Yu-Tang; Cai, Shi-Xiong; Ohashi, Mariko; Watanabe, Takao; Nakatsuka, Haruo; Kawai, Toshio; Ikeda, Masayuki
- Abstract
Personal monitoring of 8-hour time-weighted average intensity of exposure with diffuse samplers and analysis of shift-end urine for total trichloro-compounds (TTC) and other metabolites were conducted in two groups of workers in China, one (121 subjects) exposed to tetrachloroethylene (TETRA) alone, and the other (38 subjects) exposed to a mixture of TETRA and trichloroethylene (TRI). Urinalysis was also performed on samples from 103 non-exposed controls. A linear exposure-excretion relationship could be observed in both groups of workers. Comparison of these results with those of Japanese TETRA-workers suggested the presence of ethnic difference in TETRA metabolism. Urinary metabolite levels were markedly lower in the mixed (TETRA + TRI) exposure group as compared to previous findings in a group exposed to TRI alone. The observation indicates that metabolism of TRI is suppressed by the co-exposure to TETRA in humans.
- Publication
American Journal of Industrial Medicine, 1989, Vol 16, Issue 6, p675
- ISSN
0271-3586
- Publication type
Article
- DOI
10.1002/ajim.4700160607