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- Title
Human thymic stromal lymphopoietin promotes dendritic cell-mediated CD4<sup>+</sup> T cell homeostatic expansion.
- Authors
Watanabe, Norihiko; Hanabuchi, Shino; Soumelis, Vassili; Wei Yuan; Ho, Stephen; Malefyt, Rene de Waal; Yong-Jun Liu
- Abstract
T cell homeostasis is a self-regulating process for maintaining the size of the peripheral T cell pool. Although dendritic cells (DCs) seem to be important in T cell homeostasis, the molecular regulation of DC-mediated T cell homeostasis is unknown. We show that human DCs activated by thymic stromal lymphopoietin (TSLP) induced a robust expansion of autologous CD4+ T cell populations, which depended on self peptide-major histocompatibility complex. The proliferating T cells adopted and maintained a central memory polyclonal phenotype and could differentiate into T helper type 1 or type 2 effector cells. These results, together with findings of TSLP expression in epithelial cells of mucosal lymphoid tissues and thymus, indicate that TSLP is involved in DC-mediated CD4+ T cell homeostasis.
- Subjects
HOMEOSTASIS; T cells; DENDRITIC cells; THYMIC hormones; CD4 antigen; CELL populations; MAJOR histocompatibility complex; CELL proliferation; PHENOTYPES
- Publication
Nature Immunology, 2004, Vol 5, Issue 4, p426
- ISSN
1529-2908
- Publication type
Article
- DOI
10.1038/ni1048