We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Individual responses of rodents in modelling of affective disorders and in their treatment: prospective review.
- Authors
Einat, Haim; Ezer, Itamar; Kara, Nirit Z; Belzung, Catherine
- Abstract
Introduction: Lack of good animal models for affective disorders, including major depression and bipolar disorder, is noted as a major bottleneck in attempts to study these disorders and develop better treatments. We suggest that an important approach that can help in the development and use of better models is attention to variability between model animals. Results: Differences between mice strains were studied for some decades now, and sex differences get more attention than in the past. It is suggested that one factor that is mostly neglected, individual variability within groups, should get much more attention. The importance of individual differences in behavioral biology and ecology was repeatedly mentioned but its application to models of affective illness or to the study of drug response was not heavily studied. The standard approach is to overcome variability by standardization and by increasing the number of animals per group. Conclusions: Possibly, the individuality of specific animals and their unique responses to a variety of stimuli and drugs, can be helpful in deciphering the underlying biology of affective behaviors as well as offer better prediction of drug responses in patients.
- Subjects
ECOLOGY; AFFECTIVE disorders; BIPOLAR disorder; RODENTS; ORDER-disorder models
- Publication
Acta Neuropsychiatrica, 2018, Vol 30, Issue 6, p323
- ISSN
0924-2708
- Publication type
Article
- DOI
10.1017/neu.2018.14