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- Title
Q10 coenzyme supplementation effect on relative liver weight and density in dysmetabolism and exercise (Note II).
- Authors
Chiş, Bogdan Augustin; Giurgea, Natalia; Moldovan, Remus; Mureşan, Adriana
- Abstract
Background. Data obtained on the administration of coenzyme Q10 (CoQ10) on heart weight in trained animals led us to study the effects of administration on relative weight and density of the liver. Aims. We aimed to study the changes induced in liver weight and volume by exercise and CoQ10 supplementation in experimental dysmetabolic conditions. Methods. The experiment was conducted on 12 groups (n = 10 animals/group) of adult male Wistar rats, with three types of diet: standard, high-carbohydrate, and high-fat, supplemented or not with CoQ10, sedentary or exercise trained. 6 groups were subjected to daily exercise (swimming) for one hour per day for 4 weeks, the other half were sedentary. At the end of the experiment, the animals were sacrificed, body weight and liver weight and volume were measured. Statistical analysis was performed using the SPSS 20 and Excel 2010 tools. Results. The relative liver weight was significantly influenced only by physical training. Liver density was influenced by both physical training and CoQ10 supplementation. Conclusions. In trained animals with a high calorie diet, a reduction of relative liver weight was observed, regardless of CoQ10 supplementation. Sedentary animals with CoQ10 supplementation had an increased liver density, regardless of the type of diet.
- Subjects
COENZYMES; DIETARY supplements; LIVER physiology; METABOLISM; EXERCISE physiology
- Publication
Palestrica of the Third Millennium Civilization & Sport, 2015, Vol 16, Issue 2, p102
- ISSN
1582-1943
- Publication type
Article