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- Title
Healthy Zerumbone: From Natural Sources to Strategies to Improve Its Bioavailability and Oral Administration.
- Authors
Ibáñez, María Dolores; Sánchez-Ballester, Noelia M.; Blázquez, María Amparo
- Abstract
Zerumbone is a multifunctional compound with antimicrobial, antitumor, hyperalgesic, antioxidant and anti-inflammatory applications, and constitutes a point molecule for the future synthesis of derivatives with improved efficiency. This monocyclic sesquiterpenoid is found in high content in wild ginger (Zingiber zerumbet Smith), a perennial herb with economic importance as an ornamental as well as a medicinal plant. The presence of zerumbone is a distinctive feature that allows identification and differentiation from other species, not only in Zingiber, but also in Curcuma, Alpinia, Boesenbergia, Ethlingera and Ammomum spp., as well as related families (Costaceaee). To successfully use zerumbone in areas such as medicine, food and agriculture, further research on improving its low solubility and bioavailability, as well as its preservation, is a major current priority. In addition, despite its promising pharmacological activities, preclinical and clinical studies are required to demonstrate and evaluate the in vivo efficacy of zerumbone.
- Subjects
ORAL drug administration; BIOAVAILABILITY; MEDICINAL plants; ZINGIBER; ALPINIA; CURCUMA
- Publication
Plants (2223-7747), 2023, Vol 12, Issue 1, p5
- ISSN
2223-7747
- Publication type
Article
- DOI
10.3390/plants12010005