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- Title
Complement.
- Authors
Monach, Paul A.
- Abstract
The role of complement in human autoimmune, inflammatory, and infectious diseases is reviewed, focusing on clinical applicability. A typical case is presented in which serum testing for C3 and C4 is performed to help assess a syndrome with a broad differential diagnosis. The review includes a discussion of complement deficiency states, consumption of complement by diseases characterized by immune‐complex formation and deposition, usefulness and interpretation of laboratory tests for complement, and development of drugs targeting specific components of the complement pathway for a growing number of indications.
- Subjects
BLOOD serum analysis; COMMUNICABLE disease diagnosis; AUTOIMMUNE disease diagnosis; COMMUNICABLE diseases; COMPLEMENT (Immunology); INFLAMMATION; BLOOD chemical analysis; AUTOIMMUNE diseases; DIFFERENTIAL diagnosis; TREATMENT effectiveness; MEDICAL practice; BLOOD testing; DRUG development; THERAPEUTICS
- Publication
Arthritis & Rheumatology, 2024, Vol 76, Issue 1, p1
- ISSN
2326-5191
- Publication type
Article
- DOI
10.1002/art.42671