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- Title
DNA Methylation of the TNF-α Promoter Region in Peripheral Blood Monocytes and the Cortex of Human Alzheimer's Disease Patients.
- Authors
Kaut, Oliver; Ramirez, Alfredo; Pieper, Heike; Schmitt, Ina; Jessen, Frank; Wüllner, Ullrich
- Abstract
Background: The cytokine tumor necrosis factor-alpha (TNF-α) is elevated in the blood of Alzheimer's disease (AD) patients. Epigenetic DNA modifications of the TNF-α promoter may account for the observed upregulation. Methods: We analyzed blood samples of 50 AD patients and 55 controls plus 4 AD and 4 control cortex samples using bisulfite sequencing PCR. Results: A significant hypomethylation of the TNF-α promoter was found in AD patients' brains but not in their blood. Cortical TNF-α promoter DNA was higher methylated than blood-derived DNA, both in AD patients and controls. Conclusion: In AD patients, epigenetic mechanisms of TNF-α gene regulation, like aberrant DNA methylation, are not relevant in blood. © 2014 S. Karger AG, Basel
- Publication
Dementia & Geriatric Cognitive Disorders, 2014, Vol 38, Issue 1/2, p10
- ISSN
1420-8008
- Publication type
Journal Article
- DOI
10.1159/000357126