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- Title
Genetic Associations of Autopsy-Confirmed Vascular Dementia Subtypes.
- Authors
Jones, Emma L.; Kalaria, Rajesh N.; Sharp, Sally I.; O'Brien, John T.; Francis, Paul T.; Ballard, Clive G.
- Abstract
Background/Aims: Genetic risk factors have not been clearly established for vascular dementias (VaD) related to stroke and cerebrovascular disease. Methods: Samples were genotyped for APOE, MTHFR and ICAM. Aβ levels and choline acetyltransferase (ChAT) activities were assayed in controls and individuals with VaD. Results: Associations were found between the APOE-ε4 allele and mixed dementia, infarct/stroke dementia and subcortical ischemic vascular dementia (SIVD), and higher Aβ1-42 levels and decreased ChAT activity. MTHFR was more associated with SIVD, mixed dementia, and lower ChAT activity. Conclusions: The study demonstrates important differences in the genetic associations of VaD and begins to clarify the genetic basis of key pathological substrates. Copyright © 2011 S. Karger AG, Basel
- Subjects
VASCULAR dementia; ALZHEIMER'S disease; ANALYSIS of variance; AUTOPSY; CEREBROVASCULAR disease; COMPUTER software; T-test (Statistics); DATA analysis; GENETICS
- Publication
Dementia & Geriatric Cognitive Disorders, 2011, Vol 31, Issue 4, p247
- ISSN
1420-8008
- Publication type
Article
- DOI
10.1159/000327171