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- Title
Outcome of conservative treatment of primary vesicoureteral reflux in 87 Thai children in a single center.
- Authors
VACHVANICHSANONG, PRAYONG; DISSANEEWATE, PORNSAK; LIM, APIRADEE; GEATER, ALAN
- Abstract
Aim: To evaluate the outcome of primary vesicoureteral reflux (VUR) using conservative treatment. Methods: Eighty-seven children with primary VUR who had been treated with a conservative medical regimen and monitored through a yearly cystogram were recruited for the study. The study was conducted at the Pediatric Nephrology Clinic in Songklanagarind Hospital, the major tertiary care center in southern Thailand. Statistical analyses using Kaplan–Meier survival curves, chi-squared test, Fisher’s exact test and multivariate analysis with Cox regression were performed. Results: The study group consisted of 41 boys and 46 girls, with a total of 133 VUR. The age of the boys was significantly lower than that of the girls ( P < 0.001). Resolution of the low grades (grades I–III) of VUR was significantly more frequent than that of the high grades (grades IV–V) (68/95, 72% vs 14/38, 37%; P < 0.001). Using the Kaplan–Meier survival analysis and log-rank test, the resolutions of VUR in boys versus girls, and age <1 years versus ≥1 years were not significantly different ( P = 0.2252 and 0.4756, respectively). Low-grade VUR and unilateral VUR had significantly higher probabilities of resolution than high-grade VUR and bilateral VUR, respectively ( P = 0.0041 and 0.0467, respectively). Multivariate Cox regression analysis indicated that among low-grade VUR, boys and unilateral VUR had significantly higher probabilities of resolution. Among the high-grade VUR, neither sex nor laterality had a significant effect on the probabilities of VUR resolution. Conclusion: This study offers more evidence that children with low-grade VUR have a higher chance of reflux resolution if they are boys and have only unilateral VUR. There is still no good guide for resolution of reflux in children with high-grade VUR.
- Subjects
THAILAND; VESICO-ureteral reflux in children; URETER diseases; PEDIATRIC urology diagnosis; STATISTICS
- Publication
International Journal of Urology, 2006, Vol 13, Issue 11, p1393
- ISSN
0919-8172
- Publication type
Article
- DOI
10.1111/j.1442-2042.2006.01588.x