We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
BTB-ZF transcription factors, a growing family of regulators of early and late B-cell development.
- Authors
Chevrier, Stéphane; Corcoran, Lynn M
- Abstract
The differentiation of early B-cell precursors in the bone marrow into the variety of mature and effector B-cell subsets of the periphery is a complex process that requires tight regulation at the transcriptional level. Different members of the broad complex, tramtrack, bric-à-brac and zinc finger (BTB-ZF) family of transcription factors have recently been shown to have key roles in many phases of B-cell development, including early B-cell development in the bone marrow, peripheral B-cell maturation and specialization into effector cells during an immune response. This review highlights the critical functions mediated by BTB-ZF transcription factors within the B-cell lineage and emphasizes how the deregulation of these transcription factors can lead to B-cell malignancies.
- Subjects
TRANSCRIPTION factors; B cells; BONE marrow; IMMUNE response; PROTEIN precursors
- Publication
Immunology & Cell Biology, 2014, Vol 92, Issue 6, p481
- ISSN
0818-9641
- Publication type
Article
- DOI
10.1038/icb.2014.20