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- Title
Control and function of lysyl-tRNA synthetases: diversity and co-ordination.
- Authors
Nakamura, Yoshikazu; Ito, Koichi
- Abstract
Lysyl-tRNA synthetases are synthesized from two distinct genes in <em>Escherichia coli, lysS</em> (constitutively) and <em>lysU</em> (inducibly); however, the physiological significance and the differential control mechanism of these two genes have been a long-standing puzzle. Recent studies have successfully uncovered a significant control mechanism of <em>lysU</em> expression, which involves the leucine-responsive regulatory protein (Lrp) and a translational enhancer element called 'downstream box'. Moreover, it is likely that there is a mechanism underlying co-ordinate expression of <em>lysU</em> with other genes outside the leucine-Lrp regulon under harsh conditions such as low pH and anaerobiosis. A possible mechanism of lysyl-tRNA synthetase expression and function is reviewed.
- Subjects
ESCHERICHIA coli; GENES; LYSYL-tRNA synthetase; PROTEINS; LEUCINE
- Publication
Molecular Microbiology, 1993, Vol 10, Issue 2, p225
- ISSN
0950-382X
- Publication type
Article
- DOI
10.1111/j.1365-2958.1993.tb01948.x