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- Title
Dose-Dense Chemotherapy Regimen for Breast Cancer Associated with Significant Decline in Ovarian Reserve.
- Authors
Chamani, Isaac J.; Gannon, Alexandra; Connell, Phillip T.; Bisen, Ajit; Kovanci, Ertug; Sangi-Haghpeykar, Haleh; Woodard, Terri; McKenzie, Laurie J.
- Abstract
Purpose: To determine the impact of dose-dense chemotherapy administration on ovarian reserve in women undergoing treatment for breast cancer. Patients and Methods: We conducted a retrospective cohort study of reproductive age women who underwent dose-dense chemotherapy regimens with doxorubicin hydrochloride and cyclophosphamide with or without paclitaxel for a new diagnosis of breast cancer. We compared pre- and post-treatment serum antimullerian hormone (AMH) levels and assessed changes in AMH over time. Results: Fifty-seven patients met inclusion criteria. Median pre-treatment AMH was 2.9 ng/mL, whereas post-treatment AMH was 0.1 ng/mL, demonstrating a dramatic reduction in AMH levels after treatment with a dose-dense regimen. This change was independent of age and was sustained over 12 months from treatment completion. Conclusions: Dose-dense chemotherapy regimens for breast cancer lead to marked and sustained decreases in AMH irrespective of patient age.
- Subjects
TEXAS; BREAST tumor diagnosis; SEX hormones; BREAST tumors; RETROSPECTIVE studies; DESCRIPTIVE statistics; DOSE-effect relationship in pharmacology; CANCER chemotherapy; LONGITUDINAL method; PRE-tests &; post-tests; MEDICAL records; ACQUISITION of data; DOXORUBICIN; OVARIAN reserve; WOMEN'S health; PACLITAXEL; CYCLOPHOSPHAMIDE
- Publication
Journal of Adolescent & Young Adult Oncology, 2024, Vol 13, Issue 3, p465
- ISSN
2156-5333
- Publication type
Article
- DOI
10.1089/jayao.2023.0079