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- Title
Apatinib for recurrent/progressive glioblastoma multiforme: A salvage option.
- Authors
Hong-Hong Zhang; Xiao-Jing Du; Mei-Ling Deng; Lie Zheng; Dun-Chen Yao; Zhi-Qiang Wang; Qun-Ying Yang; Shao-Xiong Wu
- Abstract
Purpose: The recurrent/progressive glioblastoma multiforme (GBM) carries a dismal prognosis and the definitive treatment strategy has not yet been established. This study aimed to assess the efficacy and safety of apatinib in recurrent/progressive GBM patients. Materials and methods: The clinical data of 19 recurrent/progressive GBM patients who received apatinib treatment from November 2015 to December 2019 at Sun Yat-sen University Cancer Center were collected retrospectively in this study. Objective response rate (ORR), disease control rate (DCR), progression-free survival (PFS), overall survival (OS), and treatment-related adverse events (AEs) were reviewed and assessed. Results: The overall ORR was 52.6%, and the DCR was 73.7%. Median PFS and OS were 5.1 and 10.4 months, respectively. The 6-month PFS and OS rates were 38.9% and 68.4%, respectively. The 12-month PFS and OS rates were 16.7% and 36.8%, respectively. The treatment-related toxicities were generally welltolerated. The most common grade 3/4 AEs were hand-foot syndrome (36.8%) and hypertension (21.1%). Conclusion: Our study showed that apatinib therapy provided a better salvaging option for recurrent/progressive GBM patients and the toxicity was manageable.
- Subjects
SUN Yat-Sen University (Guangdong, China); GLIOBLASTOMA multiforme; APATINIB; HAND-foot syndrome; ADVERSE health care events; PROGRESSION-free survival; EMISSION control; SALVAGE logging; OVERALL survival
- Publication
Frontiers in Pharmacology, 2022, Vol 13, p1
- ISSN
1663-9812
- Publication type
Article
- DOI
10.3389/fphar.2022.969565