We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
CDX-2 homeobox gene expression in human gastric carcinoma and precursor lesions.
- Authors
Hyung-Seok Kim; Ji-Shin Lee; Jean-Noel Freund; Kyung-Whan Min; Jeong-Soo Lee; Wan Kim; Sang-Woo Juhng; Chang-Soo Park
- Abstract
Background: Recent studies have demonstrated that CDX-2 is expressed in the intestinal metaplasia of the stomach and intestinal-type gastric cancer. To address the role of CDX-2 in carcinogenesis of gastric carcinomas of intestinal type, the expression of CDX-2 in gastric carcinoma and precursor lesions were examined using immunohistochemistry. Methods: A total of 160 specimens diagnosed as gastric carcinomas or non-invasive neoplasia from 158 patients were analyzed for CDX-2 expression by immunochemical methods. Patients were classified into histopathologic subgroups according to the Padova international classification: 60 cases of low-grade non-invasive neoplasia, 55 cases of high grade, and 45 cases of invasive intestinal-type adenocarcinoma. The CDX-2 expression in non-neoplastic gastric mucosa including intestinal metaplasia was also evaluated in the areas included in the histologic sections. Results: The CDX-2 expression was localized in the epithelial cell nuclei in the area of intestinal metaplasia with or without dysplasia and carcinoma, consistent with its role as a transcriptional regulator. No CDX-2 reactivity was noted in the normal mucosa in all cases. The CDX-2 expression was detected in 73.3% of low-grade cases, 85.5% of high-grade cases and 91.1% of intestinal-type adenocarcinoma cases. In the gastric mucosa with intestinal metaplasia, 89.7% of the samples were positive. The CDX-2-expressing cells in intestinal metaplasia were more prevalent than in dysplasia and carcinoma. Expression of CDX-2 showed a statistically significant positive correlation with increasing grade of dysplasia and carcinoma. Conclusions: These findings suggest that CDX-2 expression in stomach cancer may be a marker of the progression of gastric carcinogenesis, and that its activation may represent an early event. © 2005 Blackwell Publishing Asia Pty Ltd
- Subjects
IMMUNOHISTOCHEMISTRY; ADENOCARCINOMA; METAPLASIA; GASTRIC mucosa; CANCER; DYSPLASIA
- Publication
Journal of Gastroenterology & Hepatology, 2006, Vol 21, Issue 2, p438
- ISSN
0815-9319
- Publication type
Article
- DOI
10.1111/j.1440-1746.2005.03933.x