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- Title
BRIEF COMMUNICATION: Efficacy of ribavirin plus interferon α on viraemia of GB virus-C/hepatitis G virus: Comparison with interferon α alone.
- Authors
KAO, JIA-HORNG; LAI, MING-YANG; CHEN, WENDY; CHEN, PEI-JER; CHEN, DING-SHINN; Chen, Ding-Shinn
- Abstract
We investigated the efficacy of ribavirin plus interferon (IFN) α on GB virus-C (GBV-C)/hepatitis G virus (HGV) viraemia and compared it with that of interferon α alone in patients coinfected with hepatitis C virus (HCV) and GBV-C/HGV. Serum HCV and GBV-C/HGV-RNA were studied in eight patients with HCV and GBV-C/HGV coinfection, five received IFNα and three received oral ribavirin plus IFNα. Mean serum GBV-C/HGV titre at the end of therapy was significantly lower than the titre just before therapy and patients with lower pretreatment titre had a better sustained response rate. Sustained virological response of GBV-C/HGV to IFNα alone and ribavirin plus IFNα at the end of follow up was observed in one each, respectively. Thus, GBV-C/HGV in patients with HCV and GBV-C/HGV coinfection does respond to IFNα and ribavirin plus IFNα may not induce a higher sustained response.
- Subjects
VIRAL hepatitis; RIBAVIRIN; INTERFERONS; COMBINATION drug therapy; DRUG therapy; DRUG efficacy
- Publication
Journal of Gastroenterology & Hepatology, 1998, Vol 13, Issue 12, p1249
- ISSN
0815-9319
- Publication type
Article
- DOI
10.1111/j.1440-1746.1998.tb00613.x