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- Title
Clinical features and prognosis of prostate cancer with high-grade prostatic intraepithelial neoplasia.
- Authors
Donghyun Lee; Chunwoo Lee; Taekmin Kwon; Dalsan You; In Gab Jeong; Jun Hyuk Hong; Hanjong Ahn; Choung-Soo Kim
- Abstract
Purpose: To evaluate the clinical features and biochemical recurrence (BCR) in prostate cancer (PCa) with high-grade prostatic intraepithelial neoplasia (HGPIN). Materials and Methods: We retrospectively analyzed the medical records of 893 patients who underwent a radical prostatectomy for PCa between 2011 and 2012 at Asan Medical Center; 752 of these patients who did not receive neoadjuvant or adjuvant therapy and were followed up for more than 1 year were included. The cohort was divided into two groups—patients with and without HGPIN—and their characteristics were compared. The Cox proportional hazards model was used to analyze factors affecting BCR. Results: In total, 652 study patients (86.7%) had HGPIN. There were no significant differences in preoperative factors between the two groups, including age (p=0.369) and preoperative prostate-specific antigen concentration (p=0.234). Patients with HGPIN had a higher Gleason score (p=0.012), more frequent multiple tumor (p=0.013), and more perineural invasion (p=0.012), but no other postoperative pathologic characteristics were significantly different between the two groups. There were no significant differences in BCR (13.0% vs. 11.5%, p=0.665) and HGPIN was not associated with BCR (p=0.745). In multivariate analysis, only the T stage (p<0.001) was associated with BCR. Conclusions: PCa patients with HGPIN have a higher Gleason score, more frequent multiple tumors, and more perineural invasion than those without HGPIN. The presence of HGPIN is not an independent predictor of BCR.
- Subjects
PROSTATE cancer prognosis; ENDOCRINE gland tumors; PROSTATECTOMY; ADJUVANT treatment of cancer; PROPORTIONAL hazards models
- Publication
Korean Journal of Urology, 2015, Vol 56, Issue 8, p565
- ISSN
2005-6737
- Publication type
Article
- DOI
10.4111/kju.2015.56.8.565