We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Effectiveness of Valproic Acid in the Treatment of Sydenham's Chorea and a Literature Review.
- Authors
Özgün, Nezir; Akdeniz, Osman
- Abstract
There is still no evidence-based guideline and consensus on the treatment Sydenham's Chorea (SC). The first-line medication preference of specialists depends on personal experience and is variable. In this study, we evaluate the treatment results of pediatric patients who were treated with valproic acid (VPA). The medical records of 17 patients diagnosed with SC were reviewed retrospectively. The mean time to clinical improvement was found as approximately 5 days, the mean duration of remission as 13.60 ± 3.94 weeks and the mean duration of medication use was found as 17.96 ± 3.81 weeks. No side effects were observed in any of the patients and relapse occurred in 2 patients. A positive correlation was found between the initial C-reactive protein (CRP) level and the duration of medication use. Until evidence-based guidelines are established, VPA can be used as an effective, safe, and inexpensive first-line treatment option, especially in pediatric patients.
- Subjects
CHOREA; PATIENT safety; TREATMENT effectiveness; RETROSPECTIVE studies; DESCRIPTIVE statistics; DISEASE remission; TREATMENT duration; VALPROIC acid; MEDICAL records; ACQUISITION of data; DRUG efficacy; DISEASE relapse; RHEUMATIC fever; C-reactive protein; MEDICAL care costs; EVALUATION; SYMPTOMS; CHILDREN
- Publication
Clinical Pediatrics, 2024, Vol 63, Issue 6, p798
- ISSN
0009-9228
- Publication type
Article
- DOI
10.1177/00099228231194411