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- Title
External validation of the prognostic index in acute paraquat poisoning.
- Authors
Kim, D. S.; Kang, C.; Kim, D. H.; Kim, S. C.; Lee, S. H.; Jeong, J. H.; Kang, T. S.; Jung, S. M.; Lee, S. B.; Lee, K. W.; Kim, R. B.
- Abstract
Objective: Some studies have evaluated the prognostic indicators associated with acute paraquat (PQ) poisoning. In this study, we externally validated the Yamaguchi index, which showed a good prognostic relevance in predicting the outcome of PQ poisoning. Methods: A retrospective analysis of 297 patients was performed. The Yamaguchi index was calculated using the following equation: Eq1 = (K+ × HCO3−)/(Creatinine × 0.088)(mEq/L) against time from PQ ingestion (T). The patients were divided into three groups: group A: Eq1 > 1500 − 399 × log T, group B: 930 − 399 × log T < Eq1 ≤ 1500 − 399 × log T, and group C: Eq1 ≤ 930 − 399 × log T). Results: The overall mortality rate was 65.3% (194 of 297). The mortality rates of the three groups stratified by the Yamaguchi index were 7.1% (2 of 28), 22.4% (15 of 67), and 87.6% (177 of 202). The area under the receiver–operating characteristic curve for predicting mortality from the external validation of the Yamaguchi index was 0.842 (95% confidence interval: 0.795–0.882). Conclusion: The Yamaguchi index is a reliable prognostic factor and could be helpful in predicting mortality due to PQ poisoning.
- Subjects
PARAQUAT; HERBICIDE toxicology; HERBICIDES &; the environment; POISONING; MORTALITY
- Publication
Human & Experimental Toxicology, 2016, Vol 35, Issue 4, p366
- ISSN
0960-3271
- Publication type
Article
- DOI
10.1177/0960327115586821