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- Title
Imprint Immunocytochemistry of Estrogen Receptors in Breast Carcinoma.
- Authors
Moriya, Takuya; Manabe, Toshiaki; Tsukayama, Chotatsu; Yamashita, Koshi; lpponsugi, Satoshi; Sonoo, Hiroshi; Senoo, Tsuneaki
- Abstract
To clarify the accuracy of immunocytochemical detection of estrogen receptors (ER) in breast carcinomas using cytological materials, imprint specimens from tumor tissue were compared with frozen tissue sections and tumors analyzed by the dextran coated charcoal (DCC) method and enzyme immunoassay (EIA). Out of 50 cases examined by imprint immunocytochemistry, there were 39 ER positive cases (78.0% positivity). The positivity in the imprint materials agreed with that of the DCC in 36 out of 40 cases (85.0%), with 100% sensitivity and 60.0% specificity. The two methods statistically correlated with each other in their positivity and grade (p<0.001). The positivity and grades of imprint and frozen immunocytochemistry as well as those of im print immunocytochemistry and the EIA agreed almost perfectly with each other. As a result of the present study, we concluded that immunocytochemical detection of ER is indeed relia ble, as accurate as other procedures. We recommend that aspiration biopsy cytology (ABC) be used for morphological examination and ER immunocytochemistry when adequate materials are available and that imprint materials be used when ABC materials are inadequate and fresh tis sue is available at the time of surgery.
- Publication
Japanese Journal of Clinical Oncology, 1990, Vol 20, Issue 2, p159
- ISSN
0368-2811
- Publication type
Article