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- Title
Effects of Granulocyte Transfusion and Combination Antibiotic Therapy on Documented Septicemia in Patients with Acute Leukemia.
- Authors
SHIMOYAMA, MASANORI; MINATO, KEISUKE; TAKENAKA, TAKEAKI; KITAHARA, TAKESHI; KONDA, CHIHIRO
- Abstract
A total of 30 episodes of documented septicemia in 25 patients with acute leukemia have been analysed to evaluate the efficacy of granulocyte transfusion therapy. Almost 90% of the septicemia was caused by gram-negative bacteria such as Pseudomonas aeruginosa, Escherichia coli and Klebsiella pneumoniae. The results showed that in six out of 23 episodes (26.0%) patients treated with combination antibiotic therapy alone responded, whereas in six out of seven episodes (85.7%) patients given granulocyte transfusion plus combination antibiotic therapy responded. The difference was statistically significant (p < 0.05). Granulocyte transfusion was most effective in patients with aplastic or hypoplastic marrows who failed to recover. The infecting organisms that demonstrated in vitro sensitivity to none or only one of the original antibiotics were not eliminated by the antibiotic therapy, while 50% of the patients who were treated with more than two antibiotics to which the infecting organisms were sensitive were cured. More responses were observed in the transfusion group. Bone marrow status, appropriate antimicrobial agents, and early initiation of transfusion appear to be very important in producing a beneficial clinical response.
- Publication
Japanese Journal of Clinical Oncology, 1979, Vol 9, Issue 1, p59
- ISSN
0368-2811
- Publication type
Article