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- Title
Global evaluation of lineage-specific human papillomavirus capsid antigenicity using antibodies elicited by natural infection.
- Authors
Kamuyu, Gathoni; Coelho da Silva, Filomeno; Tenet, Vanessa; Schussler, John; Godi, Anna; Herrero, Rolando; Porras, Carolina; Mirabello, Lisa; Schiller, John T.; Sierra, Mónica S.; Kreimer, Aimée R.; Clifford, Gary M.; Beddows, Simon
- Abstract
Human Papillomavirus (HPV) type variants have been classified into lineages and sublineages based upon their whole genome sequence. Here we have examined the specificity of antibodies generated following natural infection with lineage variants of oncogenic types (HPV16, 18, 31, 33, 45, 52 and 58) by testing serum samples assembled from existing archives from women residing in Africa, The Americas, Asia or Europe against representative lineage-specific pseudoviruses for each genotype. We have subjected the resulting neutralizing antibody data to antigenic clustering methods and created relational antigenic profiles for each genotype to inform the delineation of lineage-specific serotypes. For most genotypes, there was evidence of differential recognition of lineage-specific antigens and in some cases of a sufficient magnitude to suggest that some lineages should be considered antigenically distinct within their respective genotypes. These data provide compelling evidence for a degree of lineage specificity within the humoral immune response following natural infection with oncogenic HPV. Human Papillomaviruses (HPV) are classified in lineages based on their sequence. Here, the authors test neutralizing activity of sera from naturally infected women against vaccine-preventable HPV variants, delineating lineage-specific antibody responses.
- Subjects
PAPILLOMAVIRUSES; HUMAN papillomavirus; SERUM; WHOLE genome sequencing; HUMORAL immunity; IMMUNOGLOBULINS; ANTIBODY formation
- Publication
Nature Communications, 2024, Vol 15, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-024-45807-w