We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Muscle abnormalities worsen after post-exertional malaise in long COVID.
- Authors
Appelman, Brent; Charlton, Braeden T.; Goulding, Richie P.; Kerkhoff, Tom J.; Breedveld, Ellen A.; Noort, Wendy; Offringa, Carla; Bloemers, Frank W.; van Weeghel, Michel; Schomakers, Bauke V.; Coelho, Pedro; Posthuma, Jelle J.; Aronica, Eleonora; Joost Wiersinga, W.; van Vugt, Michèle; Wüst, Rob C. I.
- Abstract
A subgroup of patients infected with SARS-CoV-2 remain symptomatic over three months after infection. A distinctive symptom of patients with long COVID is post-exertional malaise, which is associated with a worsening of fatigue- and pain-related symptoms after acute mental or physical exercise, but its underlying pathophysiology is unclear. With this longitudinal case-control study (NCT05225688), we provide new insights into the pathophysiology of post-exertional malaise in patients with long COVID. We show that skeletal muscle structure is associated with a lower exercise capacity in patients, and local and systemic metabolic disturbances, severe exercise-induced myopathy and tissue infiltration of amyloid-containing deposits in skeletal muscles of patients with long COVID worsen after induction of post-exertional malaise. This study highlights novel pathways that help to understand the pathophysiology of post-exertional malaise in patients suffering from long COVID and other post-infectious diseases.In this longitudinal, case-controlled, cohort design study, authors show that post-exertional malaise is associated with severe exercise-induced myopathy, local and systemic metabolic disturbances and infiltration of amyloid-containing deposits in skeletal muscles of patients with long COVID.
- Publication
Nature Communications, 2024, Vol 15, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-023-44432-3