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- Title
Fornix Integrity Is Differently Associated With Cognition in Healthy Aging and Non-amnestic Mild Cognitive Impairment: A Pilot Diffusion Tensor Imaging Study in Thai Older Adults.
- Authors
Srisaikaew, Patcharaporn; Wongpakaran, Nahathai; Anderson, Nicole D.; Chen, J. Jean; Kothan, Suchart; Varnado, Pairada; Unsrisong, Kittisak; Mahakkanukrauh, Pasuk
- Abstract
Damage to the fornix leads to significant memory impairment and executive dysfunction and is associated with dementia risk. We sought to identify if fornix integrity and fiber length are disrupted in mild cognitive impairment (MCI) and how they associate with cognition. Data from 14 healthy older adult controls (HCs) and 17 subjects with non-amnestic MCI (n-aMCI) were analyzed. Diffusion tensor imaging (DTI) at 1.5 Tesla MRI was performed to enable manual tracing of the fornix and calculation of DTI parameters. Higher fractional anisotropy of body and column of the fornix was associated with better executive functioning and memory, more strongly in the HC than in the n-aMCI group. Fornix fiber tract length (FTL) was associated with better executive function, more strongly in the n-aMCI than in the HC group, and with better memory, more strongly in the HC than in the n-aMCI group. These results highlight a decline in the contributions of the fornix to cognition in n-aMCI and suggest that maintenance of fornix FTL is essential for sustaining executive functioning in people with n-aMCI.
- Subjects
AMNESTIC mild cognitive impairment; DIFFUSION tensor imaging; EXECUTIVE function; OLDER people; DIAGNOSTIC imaging
- Publication
Frontiers in Aging Neuroscience, 2020, Vol 12, pN.PAG
- ISSN
1663-4365
- Publication type
Article
- DOI
10.3389/fnagi.2020.594002