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- Title
Performance Evaluation of a Novel Potentiometric Membrane Sensor for Determination of Atorvastatin in Pharmaceutical Preparations.
- Authors
Ahmadi, Farhad; Asaadi, Nasim
- Abstract
A novel potentiometric ion-selective PVC membrane sensor for analysis of atorvastatin (AT) in pharmaceutical preparations based on atorvastatin-(tetraphenyl borate), (AT-(TPB)2) as sensing element, tetraphenyl borate as additive and tris-2-ethyl-hexyl phosphate (TOP) as plasticizer solvent was prepared. The electrode shows a good Nernestian response over the concentration range of 0.09-5586 µg mL-1 of AT with slope of 30.1±0.1 mV/decade and limit of detection0.056µg mL-1.The response time of sensor is fats (less than 10 sec)and could be used for about one month in the pH range of 4.5-8.0. The electrode exhibit good selectivity for the AT in the presence of large amount of co-drugs and inorganic cations. The method is precise and accurate with mean relative standard deviation of <2%. Atorvastatin is determined successfully in several tablets by the proposed membrane.
- Subjects
POTENTIOMETRY; ATORVASTATIN; TETRAPHENYLBORATES; PLASTICIZERS; ELECTRODES
- Publication
Iranian Journal of Pharmaceutical Research, 2013, Vol 12, Issue 4, p645
- ISSN
1735-0328
- Publication type
Article