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- Title
SARS-CoV-2 Omicron Variant Severity in Ontario, Canada—Reply.
- Authors
Ulloa, Ana Cecilia; Buchan, Sarah A.; Brown, Kevin A.
- Abstract
Comment & Response B In Reply b Dr Zeng mentions potential confounding due to prior SARS-CoV-2 infection, which was not considered in our original analysis.[1] The arrival of the Omicron variant wave was a turning point in the COVID-19 pandemic, with widespread reports of reduced severity compared with prior variants. First, to adjust for prior infection while ignoring underdetection, we used a regression-based adjustment with prior infection as a binary variable, which yielded an HR for prior infection of 0.30 (95% CI, 0.04-2.14) and an HR for Omicron severity of 0.40 (95% CI, 0.30-0.54). These estimates were built into an instrumental variable for the probability of prior infection (1 = prior infection, 0.079 = no prior infection and Omicron, and 0.012 = no prior infection and Delta), yielding an estimated HR for prior infection of 0.27 (95% CI, 0.03-2.20) and an overall HR estimate of Omicron severity compared with Delta for hospitalization or death of 0.44 (95% CI, 0.32-0.61).
- Publication
JAMA: Journal of the American Medical Association, 2022, Vol 328, Issue 4, p395
- ISSN
0098-7484
- Publication type
Article
- DOI
10.1001/jama.2022.9262