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- Title
Phytochemical composition, antifungal activity, in vitro and in vivo toxicity of Syzygium cumini (L.) Skeels leaves extract.
- Authors
Figueirêdo Júnior, Ernani Canuto; Wanderley Cavalcanti, Yuri; Brito Lira, Andressa; Freire Pessôa, Hilzeth de Luna; Silva Lopes, Wilton; Romário da Silva, Diego; Almeida Freires, Irlan; Luiz Rosalen, Pedro; Melo de Brito Costa, Edja Maria; Vieira Pereira, Jozinete
- Abstract
This study determined phytochemical composition, antifungal activity and toxicity in vitro and in vivo of Syzygium cumini leaves extract (Sc). Thus, was characterized by gas chromatography coupled to mass spectrometry and submitted to determination of Minimum Inhibitory (MIC) and Fungicidal concentrations (MFC) on reference and clinical strains of Candida spp. and by growth kinetics assays. Toxicity was verified using in vitro assays of hemolysis, osmotic fragility, oxidant and antioxidant activity in human erythrocytes and by in vivo acute systemic toxicity in Galleria mellonella larvae. Fourteen different compounds were identified in Sc, which showed antifungal activity (MIC between 31.25-125 µg/mL) with fungistatic effect on Candida. At antifungal concentrations, it demonstrated low cytotoxicity, antioxidant activity and neglible in vivo toxicity. Thus, Sc demonstrated a promising antifungal potential, with low toxicity, indicating that this extract can be a safe and effective alternative antifungal agent.
- Subjects
SYZYGIUM; GREATER wax moth; MASS spectrometry; ANTIFUNGAL agents; GAS chromatography; EXTRACTS
- Publication
Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas, 2021, Vol 20, Issue 5, p536
- ISSN
0717-7917
- Publication type
Article
- DOI
10.37360/blacpma.21.20.5.40