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- Title
Early Life Exposure to Famine and Colorectal Cancer Risk: A Role for Epigenetic Mechanisms.
- Abstract
The article focuses on a study on the role of epigenetic mechanisms in providing explanation for the association between the exposure to energy restriction, or famine, during childhood and adolescence and a lower risk of developing colorectal cancer (CRC). The study analyses data of the Netherlands Cohort Study on diet and cancer (NLCS), which included individuals who grew up during the Hunger Winter of 1944-1945 and two preceding periods of energy restriction, World War II and the Economic Depression. The study shows how exposure to a severe environmental condition during adolescence may result in epigenetic changes that later influence the development of colorectal cancer.
- Subjects
COLON cancer risk factors; ENVIRONMENTALLY induced cancer; EPIGENETICS; STARVATION; HUNGER; FAMINES; WORLD War II; GREAT Depression, 1929-1939; CANCER research
- Publication
PLoS ONE, 2009, Vol 4, Issue 11, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0007951