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- Title
Dynamic Contrast-Enhanced MRI Perfusion Parameters as Imaging Biomarkers of Angiogenesis.
- Authors
Kim, Sung Hun; Lee, Hyeon Sil; Kang, Bong Joo; Song, Byung Joo; Kim, Hyun-Bin; Lee, Hyunyong; Jin, Min-Sun; Lee, Ahwon
- Abstract
Hypoxia in the tumor microenvironment is the leading factor in angiogenesis. Angiogenesis can be identified by dynamic contrast-enhanced breast MRI (DCE MRI). Here we investigate the relationship between perfusion parameters on DCE MRI and angiogenic and prognostic factors in patients with invasive ductal carcinoma (IDC). Perfusion parameters (Ktrans, kep and ve) of 81 IDC were obtained using histogram analysis. Twenty-fifth, 50th and 75th percentile values were calculated and were analyzed for association with microvessel density (MVD), vascular endothelial growth factor (VEGF) and conventional prognostic factors. Correlation between MVD and ve50 was positive (r = 0.33). Ktrans50 was higher in tumors larger than 2 cm than in tumors smaller than 2 cm. In multivariate analysis, Ktrans50 was affected by tumor size and MVD with 12.8% explanation. There was significant association between Ktrans50 and tumor size and MVD. Therefore we conclude that DCE MRI perfusion parameters are potential imaging biomarkers for prediction of tumor angiogenesis and aggressiveness.
- Subjects
NEOVASCULARIZATION; PERFUSION; MAGNETIC resonance imaging; BIOMARKERS; TUMOR microenvironment; DUCTAL carcinoma; VASCULAR endothelial growth factors; PROGNOSIS
- Publication
PLoS ONE, 2016, Vol 11, Issue 12, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0168632