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- Title
In vitro sortase a inhibitory and antimicrobial activity of flavonoids isolated from the roots of Sophora flavescens.
- Authors
Oh, Ikhoon; Yang, Woo-Young; Chung, Soon-Chun; Kim, Tae-Yoon; Oh, Ki-Bong; Shin, Jongheon
- Abstract
series of flavonoids ( 1- 14) was isolated from the roots of Sophora flavescens. We evaluated their ability to inhibit both microbial growth and sortase A, an enzyme that plays a key role in cell wall protein anchoring and virulence in Staphylococcus aureus. Most prenylated flavonoids ( 7- 13) displayed potent inhibitory activity against gram-positive and gram-negative bacteria except E. coli, with minimum inhibitory concentrations values ranging from 4.40 to 27.7 μM, and weak or no activity against fungal strains tested. Kurarinol ( 6) was a potent inhibitor of sortase A, with an IC value of 107.7 ± 6.6 μM. A preliminary structure-activity relationship, including essential structural requirements, is described.
- Publication
Archives of Pharmacal Research, 2011, Vol 34, Issue 2, p217
- ISSN
0253-6269
- Publication type
Article
- DOI
10.1007/s12272-011-0206-0