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- Title
Synthesis of 2-substituted-6-(4 H-1,2,4-triazol-4-yl)benzo[ d]oxazoles as potential anticonvulsant agents.
- Authors
Wei, Cheng-Xi; Guan, Li-Ping; Jia, Jing-Hao; Chai, Kyu-Yun; Quan, Zhe-Shan
- Abstract
A series of 2-substituted-6-(4 H-1,2,4-triazol-4-yl)benzo[ d]oxazoles were synthesized. The anticonvulsant effect and neurotoxicity of the compounds (intraperitoneally) were evaluated with the maximal electroshock (MES) test, subcutaneous pentylenetetrazole (sc-PTZ), and rotarod tests in mice. 2-Phenyl-6-(4 H-1,2,4-triazol-4-yl)benzo[ d]oxazole ( 3g) was the most active and also had the lowest toxicity. In the anti-MES potency test, it showed median effective dose (ED50) of 29.5 mg/kg, a median toxicity dose (TD50) of 285 mg/kg, and a protective index (PI) of 9.7, which is greater than the reference drug, carbamazepine, which has a PI of 6.4.
- Publication
Archives of Pharmacal Research, 2009, Vol 32, Issue 1, p23
- ISSN
0253-6269
- Publication type
Article
- DOI
10.1007/s12272-009-1114-4