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- Title
CD200: Association with cancer stem cell features and response to chemoradiation in head and neck squamous cell carcinoma.
- Authors
Jung, Yuh‐Seog; Vermeer, Paola D.; Vermeer, Daniel W.; Lee, Sang‐Jin; Goh, Ah Ra; Ahn, Hyun‐Joo; Lee, John H.
- Abstract
ABSTRACT Background The purpose of this study was to characterize the expression of CD200, a membrane protein that functions in immune evasion, to examine its correlations with cancer stem cell (CSC)-like features and analyze its response to chemotherapy and radiation in human papillomavirus (HPV)-positive (+) and negative (−) head and neck squamous cell carcinomas (HNSCCs). Methods CD200 expression was analyzed in several HNSCC cell lines. CD200 was overexpressed in HPV(+) murine tonsil epithelial cells, its effects on Shh and Bmi-1 were examined in vitro, and tumor growth and response to chemoradiation were analyzed in vitro and in vivo. Results CD200 was diversely expressed and consistently associated with expression of Bmi-1 and Shh. Overexpression of CD200 induced Bmi-1 and Shh. Tumors grew similarly between C57BL/6 and Rag1-/- C57BL/6 mice. CD200 expression enhanced the resistance to chemoradiation only in vivo. Conclusion CD200 was related to CSC features and modulates response to chemoradiation in vivo. Attenuating this might be a potential therapeutic strategy. © 2014 Wiley Periodicals, Inc. Head Neck, 37: 327-335, 2015
- Subjects
CANCER stem cells; SQUAMOUS cell carcinoma; CANCER treatment; HEAD &; neck cancer treatment; CANCER radiotherapy; CANCER chemotherapy; IMMUNOLOGICAL tolerance; PAPILLOMAVIRUSES
- Publication
Head & Neck, 2015, Vol 37, Issue 3, p327
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.23608