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- Title
Matrix metalloproteinase-7 and matrix metalloproteinase-25 in oral tongue squamous cell carcinoma.
- Authors
Mäkinen, Laura K.; Häyry, Valtteri; Hagström, Jaana; Sorsa, Timo; Passador–Santos, Fabricio; Keski–Säntti, Harri; Haukka, Jari; Mäkitie, Antti A.; Haglund, Caj; Atula, Timo
- Abstract
Background Predicting the clinical course of early-stage oral tongue squamous cell carcinoma (SCC) is challenging. As matrix metalloproteinases (MMPs) are enzymes associated with invasion, metastasis, and poor survival in many cancers, we examined MMP-7 and MMP-25 in oral tongue SCC. Methods We used tissue microarray (TMA) technique and immunohistochemistry to study the expression of MMP-7 and MMP-25 in 73 patients with stage I to II oral tongue SCC and compared their immunoexpressions with clinical data. Results Immunohistochemistry revealed MMP-7 and MMP-25 expression in 90% ( n = 63 of 70) and 90% ( n = 64 of 71) of the tumors, respectively. MMP-7 protein expression was associated with presence of occult cervical metastases (odds ratio [OR], 3.67; p = .013), increased invasion depth (OR, 4.60; p = .005), and higher tumor grade (OR, 3.30; p = .007). MMP-7 expression was predictive for poor outcome ( p = .021). Immunostaining of MMP-25 did not correlate with any clinical parameters. Conclusion We conclude that MMP-7, but not MMP-25, expression may have prognostic significance in early-stage oral tongue SCC. © 2014 Wiley Periodicals, Inc. Head Neck 36: 1783-1788, 2014
- Subjects
MATRIX metalloproteinases; TONGUE cancer; ENDOPEPTIDASES; METALLOPROTEINASES; MICROARRAY technology
- Publication
Head & Neck, 2014, Vol 36, Issue 12, p1783
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.23539