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- Title
Postoperative spindle cell nodule after thyroidectomy: A case mimicking recurrence with anaplastic transformation of thyroid cancer.
- Authors
Kim, Sun Wook; Oh, Young Lyun; Choi, Joon Young; Lee, Ji In; Chung, Jae Hoon; Kim, Jee Soo; Smith, Russel B.
- Abstract
Background Here, we report a case of a postoperative spindle cell nodule that mimicked recurrence with anaplastic transformation after thyroidectomy. Methods The course of the disease is described. The mass was studied morphologically and immunohistochemically. Results A 31-year-old woman underwent total thyroidectomy for papillary thyroid carcinoma. A mass suspected of recurrence was found 14 months later and caused dysphagia and dyspnea. An 18F-fluorodeoxyglucose positron emission tomographic (18F-FDG-PET) scan showed a lesion with high uptake; however, a fine-needle aspiration biopsy (FNAB) was inconsistent with recurrent cancer. The mass was resected and was composed of elongated spindle cells, with eosinophilic cytoplasm within a myxoid background. Immunohistochemical staining was strongly positive for vimentin, focally positive for smooth muscle actin, desmin, and p53, and negative for cytokeratin AE1/AE3, Cam5.2, epithelial membrane antigen (EMA), and anaplastic lymphoma kinase (ALK-1). Conclusion Although postoperative spindle cell nodules are rare after thyroid surgery, it should be considered in the differential diagnosis for recurrent masses at the operative site. Head Neck, 2013
- Subjects
CASE studies; CANCER; THYROID gland surgery; DEGLUTITION disorders; DYSPNEA; NEEDLE biopsy
- Publication
Head & Neck, 2013, Vol 35, Issue 1, pE13
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.21784